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适量饮用咖啡可预防高尿酸血症和痛风

来源:贵阳痛风医院 时间:2019-01-06 15:30:00

此文原文引自国外文献,医学界目前尚无定论,建议痛友们仅做参考。


目的:关于咖啡对血尿酸影响的研究结果有争议。本研究的目的为分析咖啡对血清尿酸的影响。

方法:我们检索了MEDLINE,EMBASE,Cochrane和koreamed,搜集2015年1月前发表的所有文章。关于咖啡消费量和血尿酸水平的定量数据相关研究均包括在内。根据咖啡消费量和血尿酸水平评估有无痛风风险。

结果:共纳入1999年至2014年发表的9篇研究,包括175310名研究对象。Meta分析结果表明,咖啡可降低血尿酸水平,降低血尿酸的咖啡量存在性别差异。女性(4-6杯/天)降尿酸所需要的咖啡量多于男性(1-3杯/天)。荟萃分析表明,每天喝1杯咖啡或更多与降低痛风风险显著相关,且不论性别,均与每日咖啡摄入量呈负相关。

结论:这是咖啡对血尿酸影响相关的第一篇系统性综述。根据我们的研究,提倡适量饮用咖啡,以预防高尿酸血症和痛风。


附原文:AbstractOBJECTIVE:Study results on the effects of coffee consumption on serum uric acid (UA) have been conflicting. The aim of this study is to analyze the literature regarding the effect of coffee consumption on serum UA. METHODS:We searched MEDLINE, EMBASE, the Cochrane library, and KoreaMed for all articles published before January 2015. Studies with quantitative data on coffee consumption and serum UA level were included. Coffee consumption and serum UA level were identified with/without the risk of gout. RESULTS:Nine studies published between 1999 and 2014 were included, containing a total of 175,310 subjects. Meta-analysis demonstrated that coffee has a significantly lowering effect on serum UA, where there are gender differences in the amount of coffee required to lower serum UA. Women (4-6 cups/day) need more coffee to lower serum UA than men (1-3 cups/day). Meta-analysis showed that coffee intake of 1 cup/day or more was significantly associated with reduction of the risk of gout, with a negative correlation with the amount of daily coffee intake for both genders.CONCLUSIONS:This is the first systematic review on the effects of coffee consumption on serum UA. Based on our study, moderate coffee intake might be advocated for primary prevention of hyperuricemia and gout in both genders

引自:Park KY, Kim HJ, Ahn HS,et al. Effects of coffee consumption on serum uric acid: systematic review and meta-analysis. Semin Arthritis Rheum. 2016 Apr;45(5):580-6. doi: 10.1016/j.semarthrit.2016.01.003. Epub 2016 Jan21.

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